Anti-CD61/Integrin β3, Clone ITG/2145

Catalog Number
AM942-10ME - (10 mL (RTU))Add to cart
AM942-5ME - (6 mL (RTU))Add to cart
AX942-50DE - (50 tests - Xmatrx Elite)Add to cart
AX942-YCDE - (200 tests - Xmatrx Elite)Add to cart
MU942-5UCE - (0.5 mL (Conc.))Add to cart
MU942-UCE - (1 mL(Conc.))Add to cart
Datasheet
SDS

Spleen stained with CD61/Integrin β3

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Monoclonal anti-CD61 reacts with human integrin beta 3 (GPIIIa; vitronectin receptor beta chain). The protein detectable is a complex of CD41 and CD61. The apparent molecular weight of the GPIIIa by SDS-PAGE is 105kDa reduced and 90kDa unreduced. Ligands are fibronectin; fibrinogen; von Willebrand factor; vitronectin and thrombospondin. Residues 237-248 of GPIIIa or CD61 are critical in adhesive protein binding. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling.
Intended Use: IVD