Anti-BCL-2, Clone EP36

Catalog Number
AN723-10M - (100 tests - i6000)Add to cart
AN723-5M - (6 mL (RTU))Add to cart
AY723-50D - (50 tests - Xmatrx Elite)Add to cart
AY723-YCD - (200 tests - Xmatrx Elite)Add to cart
FB-723N - (5 slides - Xmatrx)Add to cart
FG-723N - (5 slides - Manual)Add to cart
NU723-5UC - (0.5 mL (Conc.))Add to cart
NU723-UC - (1 mL(Conc.))Add to cart

Bcl-2 (B-cell lymphoma 2), encoded in humans by the Bcl-2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death, by either inducing (pro-apoptotic) it or inhibiting it (anti-apoptotic). Bcl-2 is specifically considered as an important anti-apoptotic protein and is thus classified as an oncogene. Over expression of Bcl-2 has been shown to promote cell survival by suppressing apoptosis. It has been documented that Bcl-2 becomes deregulated in tumor cells as a result of translocation into the immunoglobulin heavy-chain locus and is therefore activated in B cell malignancies. Bcl-2 is useful in differentiation of follicular lymphoma from reactive follicular proliferation (Bcl-2 negative). In addition, Bcl-2 has been shown to be correlated with disease prognosis in breast cancer, prostate and ovarian cancer.

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Intended Use: IVD