Anti-bcl-2 Oncoprotein, Clone bcl-2/100

Catalog Number
AM287-10M - (100 tests - i6000)Add to cart
AM287-5M - (6 mL (RTU))Add to cart
AX287-50D - (50 tests - Xmatrx Elite)Add to cart
AX287-YCD - (200 tests - Xmatrx Elite)Add to cart
FG-287M - (5 slides - Manual)Add to cart
Clone 100 reacts with bcl-2 alpha oncoprotein as assessed by reaction with a 26-kD band in immunoblotting. This antibody stains the 380 cell line which carries a 14;18 chromosomal translocation. bcl-2 oncogene codes for two closely similar proteins, bcl-2 alpha and bcl-2 beta. These two proteins differ only in their carboxyl terminal sequences. bcl-2 is an integral inner mitochondrial membrane protein and is frequently overexpressed in many lymphoid malignancies. This protein also interferes with programmed cell death independent of promoting cell division. Immunohistologic studies have demonstrated that staining for bcl-2 protein can be used to distinguish neoplastic germinal centers from reactive ones.
Intended Use: IVD