Catalog Number
AN819-10M - (100 tests - i6000)Add to cart
AN819-5M - (6 mL (RTU))Add to cart
AY819-50D - (50 tests - Xmatrx Elite)Add to cart
AY819-YCD - (200 tests - Xmatrx Elite)Add to cart
FB-819N - (5 slides - Xmatrx)Add to cart
FG-819N - (5 slides - Manual)Add to cart
NU819-5UC - (0.5 mL (Conc.))Add to cart
NU819-UC - (1 mL(Conc.))Add to cart

Tonsil tissue stained with antiHuman Bcl-xusing DAB chromogen

Bcl-X, or bcl-2-like 1 protein, a member of the bcl-2 protein family, inhibits cell death or apoptosis and functions as a regulator of apoptosis. Bcl-X has two isoforms: Bcl-XL (Long), a 241-amino acid protein; and Bcl-XS (Short), a 178-amino acid protein lacking a 63-amino acid domain that is well conserved among members of the bcl-2 family. Bcl-X is typically present in the cytosol in association with the mitochondrial membrane.Bcl-x is expressed in many types of cell including lymphocytes, neuronal cells, and epithelial cells. In tumors, a high level of Bcl-x has been found in Reed Sternberg cells in Hodgkin’s disease. Overexpression of Bcl-x has been observed in primary central nervous system lymphomas that occur in immuno suppressed patients. In prostate cancer, Bcl-x expression is increased during tumor progression. Overexpression of Bcl-x in colon cancer has been linked to a poor prognosis.
Intended Use: IVD