Catalog Number
AN778-10M - (100 tests - i6000)Add to cart
AN778-5M - (6 mL (RTU))Add to cart
AY778-50D - (50 tests - Xmatrx Elite)Add to cart
AY778-YCD - (200 tests - Xmatrx Elite)Add to cart
FB-778N - (5 slides - Xmatrx)Add to cart
FG-778N - (5 slides - Manual)Add to cart

Breast stained with anti-Human Beta Catenin using DAB chromogen

Beta-Catenin is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation. Mutations of this gene are commonly found in a variety of cancers: in primary hepatocellular carcinoma, colorectal cancer, ovarial carcinoma, breast cancer, lung cancer and glioblastoma. Mutations in the BetaCatenin gene CTNNB1 leading to stabilization of Beta-Catenin in the cytoplasm and translocation to the nucleus have been implicated in various forms of tumor including familial adenomatous polyposis, fibromatosis, solitary fibrous tumors and endometrial carcinoma. A nuclear accumulation of Beta-Catenin in fibromatosis (desmoid tumor) in various locations including breast and mesentery is useful in the differentiation of this tumor from other fibroblast like lesions.
Intended Use: IVD