Anti-BOB-1, Clone SP92

Catalog Number
AN957-10M - (10 mL (RTU))Add to cart
AN957-5M - (6 mL (RTU))Add to cart
AY957-50D - (50 tests - Xmatrx Elite)Add to cart
AY957-YCD - (200 tests - Xmatrx Elite)Add to cart
NU957-5UC - (0.5 mL (Conc.))Add to cart
NU957-UC - (1 mL(Conc.))Add to cart

Lymph node stained with BOB-1

The BOB-1 / OBF-1 / OCA-B protein is a B cell-specific co-activator of the Oct1 and Oct2 transcription factors. BOB-1 facilitates transactivation of immunoglobulins and other B-cell specific genes through the binding and activation of the transcription factors Oct-1 and Oct-2. Research studies have demonstrated that BOB-1 expression is required for antigen-dependent B-cell maturation. Expression of BOB-1/OBF-1 is restricted largely to mature B-cells. In pathological conditions such as classical Hodgkin’s disease, loss of BOB-1 expression is thought, in part, to contribute to the defect in immunoglobulin gene expression by Hodgkin and Reed Sternberg cells. Expression of BOB.1/OBF.1 has been reported in follicular center cell lymphoma, diffuse large B-cell lymphoma and some cases of acute myeloid leukemia. B-CLL, marginal zone lymphoma and mantle cell lymphoma may show weak to moderate immunoreactivity.
Intended Use: RUO