Anti-c-Jun, Clone 4H9

Catalog Number
AM958-10M
(10 mL (RTU))
Qty:
AM958-5M
(6 ml (RTU))
Qty:
AX958-50D
(50 tests - Xmatrx Elite/Ultra)
Qty:
AX958-YCD
(200 tests - Xmatrx Elite/Ultra)
Qty:
MU958-5UC
(0.5 ml (Conc.))
Qty:
MU958-UC
(1 ml (Conc.))
Qty:
Datasheet
SDS

Stomach cancer stained with c-Jun

$0.00
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c-Jun is a component of the transcription factor Activator Protein 1 (AP-1) that binds and activates transcription at TPA-responsive element (TRE/AP-1) elements and appears to be a major downstream target of the Stress-activated protein kinases/Jun amino-terminal kinases (SAPK/JNK) signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins, and UV irradiation stimulates phosphorylation of c-Jun at Ser63/73 and activates c-Jun dependent transcription. c-Jun antibodies are used to study the signal-transducing transcription factor of the AP1 family. c-Jun has been implicated in several areas of cell biology including cell cycle progression through the G1 phase, transformation, and differentiation and has recently been linked to apoptosis. c-Jun is a known proto-oncogene and is found to be significantly overexpressed in lung and breast cancers, making it a viable tumor marker.
Intended Use: IVD