Anti-c-Jun, Clone 4H9

Catalog Number
AM958-10M - (10 mL (RTU))Add to cart
AM958-5M - (6 mL (RTU))Add to cart
AX958-50D - (50 tests - Xmatrx Elite)Add to cart
AX958-YCD - (200 tests - Xmatrx Elite)Add to cart
MU958-5UC - (0.5 mL (Conc.))Add to cart
MU958-UC - (1 mL(Conc.))Add to cart

Stomach cancer stained with c-Jun

c-Jun is a component of the transcription factor Activator Protein 1 (AP-1) that binds and activates transcription at TPA-responsive element (TRE/AP-1) elements and appears to be a major downstream target of the Stress-activated protein kinases/Jun amino-terminal kinases (SAPK/JNK) signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins, and UV irradiation stimulates phosphorylation of c-Jun at Ser63/73 and activates c-Jun dependent transcription. c-Jun antibodies are used to study the signal-transducing transcription factor of the AP1 family. c-Jun has been implicated in several areas of cell biology including cell cycle progression through the G1 phase, transformation, and differentiation and has recently been linked to apoptosis. c-Jun is a known proto-oncogene and is found to be significantly overexpressed in lung and breast cancers, making it a viable tumor marker.
Intended Use: IVD