Anti-CD20/MS4A1, Clone IGEL/773

Catalog Number
AM947-10M - (10 mL (RTU))Add to cart
AM947-5M - (6 mL (RTU))Add to cart
AX947-50D - (50 tests - Xmatrx Elite)Add to cart
AX947-YCD - (200 tests - Xmatrx Elite)Add to cart
MU947-5UC - (0.5 mL (Conc.))Add to cart
MU947-UC - (1 mL(Conc.))Add to cart

Tonsil stained with CD20

The CD20, which is a 33 kDa protein that traverses the cell membrane, initially expresses on pre B-cells and retains on mature B-cells. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is lost upon terminal differentiation into plasma cells. Anti-CD20 can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin's disease, particularly of lymphocyte predominant type.
Intended Use: IVD