Anti-CD8a, Clone C8/468

Catalog Number
AM929-10M - (10 mL (RTU))Add to cart
AM929-5M - (6 mL (RTU))Add to cart
AX929-50D - (50 tests - Xmatrx Elite)Add to cart
AX929-YCD - (200 tests - Xmatrx Elite)Add to cart
MU929-5UC - (0.5 mL (Conc.))Add to cart
MU929-UC - (1 mL(Conc.))Add to cart

Tonsil stained with CD8a

CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I major histocompatibility complex (MHC) molecules. The coreceptor functions as either a homodimer composed of two alpha chains (CD8 alpha/alpha) or as a heterodimer composed of one alpha and one beta chain (CD8 alpha/beta). Binding of CD8 with MHC class I molecules helps stabilize the T-cell receptor (TCR)/peptide MHC (pMHC) complex and localizes the CD8-associated protein tyrosine kinase lck (p56lck) to the CD3 complex; which aids in the activation of mature CD8+ T cells. For mature T-cells; CD4 and CD8 are mutually exclusive; so anti-CD8; generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes; and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-; and in T-lymphoblastic lymphoma/leukemia; CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a.
Intended Use: RUO