Anti-Cytokeratin 5

Catalog Number
AN853-10M - (100 tests - i6000)Add to cart
AN853-5M - (6 mL (RTU))Add to cart
AY853-50D - (50 tests - Xmatrx Elite)Add to cart
AY853-YCD - (200 tests - Xmatrx Elite)Add to cart
FB-853N - (5 slides - Xmatrx)Add to cart
FG-853N - (5 slides - Manual)Add to cart
NU853-5UC - (0.5 mL (Conc.))Add to cart
NU853-UC - (1 mL(Conc.))Add to cart

Cervical cancer stained with antiHuman Cytokeratin 5 using DAB chromogen

The mitotically active basal layers of most stratified squamous epithelia express 10% to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK5 and its corresponding partner, type I keratin CK14, both of which are essential for the formation of 8-nm filaments. CK5 and calretinin have been useful in different studies as immunohistochemical markers suggestive of mesothelioma, and their expression is analyzed for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin. CK5 labels myoepithelial cells of breast and prostate basal cells. A cocktail of CK5, CK14 and p63, has been used as sensitive and specific basal cell marker of basal-like phenotype of breast carcinoma and to differentiate normal and prostate cancer. Loss-of-function mutations in the keratin 5 gene (KRT5) affected family members and in six unrelated patients with Dowling-Degos disease (DDD), an autosomal dominant genodermatosis.
Intended Use: IVD