Anti-Cytokeratin 5 + Cytokeratin 14, Clone EP24 + EP61

Catalog Number
AN730-10M - (100 tests - i6000)Add to cart
AN730-5M - (6 mL (RTU))Add to cart
AY730-50D - (50 tests - Xmatrx Elite)Add to cart
AY730-YCD - (200 tests - Xmatrx Elite)Add to cart
FB-730N - (5 slides - Xmatrx)Add to cart
FG-730N - (5 slides - Manual)Add to cart
NU730-5UC - (0.5 mL (Conc.))Add to cart
NU730-UC - (1 mL(Conc.))Add to cart

Prostate stained with anti-CK5&14 using DAB chromogen

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. CK5 is a type II cytokeratin. Loss-of-function mutations in the keratin 5 gene (KRT5) affected family members and six unrelated patients with Dowling-Degos disease (DDD), an autosomal dominant genodermatosis. This suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage. CK5 labels myoepithelial cells of breast and prostate basal cells. CK5 and calretinin have been useful in different studies as immunohistochemical markers suggesting mesothelioma, and their expression is analyzed for the histological differentiation of adenocarcinomas, especially when facing metastatic tumors of unknown origin. Cytokeratin 14 (CK14) is a 50-kDa keratin expressed in abundance in stratified epithelial, epidermal, basal, mesothelial and myoepithelial cells in various tissues including breast and prostate. The CK14 antibody is helpful in the identification of breast cancer with a basal phenotype. It has been reported that Cytokeratin 5/14-positive breast cancers are true basal phenotype confined to BRCA1 tumors. Along with p63 and CK5, the CK14 antibody has been a useful marker for cells with basal, squamous and myoepithelial differentiation.
Intended Use: RUO