Anti-J chain

Catalog Number
AN756-10M - (100 tests - i6000)Add to cart
AN756-5M - (6 mL (RTU))Add to cart
AY756-50D - (50 tests - Xmatrx Elite)Add to cart
AY756-YCD - (200 tests - Xmatrx Elite)Add to cart
FB-756N - (5 slides - Xmatrx)Add to cart
FG-756N - (5 slides - Manual)Add to cart
NU756-5UC - (0.5 mL (Conc.))Add to cart
NU756-UC - (1 mL(Conc.))Add to cart
Datasheet
SDS

Tonsil stained with anti-Human J-chain using DAB chromogen

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J chain is a small glycopeptide and is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells that secrete polymeric immunoglobulins. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centres of the tonsils and lymph nodes. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM. J chain has been proposed to play a role in the mucosal transport of polymeric Igs by the polymeric Ig receptor. The studies show that a significant proportion of deposited mesangial immunoglobulin in IgA nephropathy is dimeric, or J chain positive. This monoclonal antibody stains J chain in cytoplasm of positve cells. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM.
Intended Use: IVD