Anti-J chain, Clone JC88

Catalog Number
AM374-10M - (100 tests - i6000)Add to cart
AM374-5M - (6 mL (RTU))Add to cart
AX374-50D - (50 tests - Xmatrx Elite)Add to cart
AX374-YCD - (200 tests - Xmatrx Elite)Add to cart
MU374-5UC - (0.5 mL (Conc.))Add to cart
MU374-UC - (1 mL(Conc.))Add to cart

Tonsil stained with Anti-J-chainusing Fast Red chromogen

J chain is a small, glycopeptide of 15 kD. It is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells that secrete polymeric immunoglobulins. J chain is linked to IgA and IgM by disulfide bonds, however, it has been detected in IgG- and IgD-containing cells. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centers of the tonsils and lymph nodes. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM. IgA monomers are linked end-to-end with J chain interposed. J chain has been proposed to play a role in the mucosal transport of polymeric Igs by the polymeric Ig receptor. The studies show that a significant proportion of deposited mesangial immunoglobulin in IgA nephropathy is dimeric, or J chain positive. The physiological role of J chain is still unclear, but it is postulated that the switch from secretory local immunity to the systemic type of local immunoreaction could have differing consequences. Possibly the local down-regulation of J chain in the IgA immunocytes could shift the production of polymeric IgA to monomers, jeopardizing secretory immunity.
Intended Use: IVD