Anti-MiTF, Clone MiTF/A13

Catalog Number
(100 tests - i6000)
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(6 ml (RTU))
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(50 tests - Xmatrx Elite/Ultra)
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(200 tests - Xmatrx Elite/Ultra)
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(5 slides - Manual)
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(0.5 ml (Conc.))
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(1 ml (Conc.))
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Melanoma tissue stained with Anti-MiTF using AEC chromogen

Micropthalmia-associated Transcription Factor (MitF) is a basic helix-loop-helix leucine zipper transcription factor involved in melanocyte and osteoclast development. Mutations in MiTF cause auditory pigmentary syndromes, such as Waardenburg Syndrome Type II, Type IIa and Tietz Syndrome in humans. There are two known isoforms of MiTF differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melanoma cells (but not other Melanoma cell lines), as well as mast cells and heart cells. MiTF plays a critical role in the differentiation of various cell types such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. This antibody recognizes serine phosphorylated and non-phosphorylated melanocytic isoforms of micropthalmia. It is useful in identifying Malignant Melanoma , and distinguishing mast cell lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epitheloid cell differentiation) express MiTF in a high percentage of cases ~90%)
Intended Use: IVD