Anti-p27 (Kip1)

Catalog Number
AN817-10M - (100 tests - i6000)Add to cart
AN817-5M - (6 mL (RTU))Add to cart
AY817-50D - (50 tests - Xmatrx Elite)Add to cart
AY817-YCD - (200 tests - Xmatrx Elite)Add to cart
FB-817N - (5 slides - Xmatrx)Add to cart
FG-817N - (5 slides - Manual)Add to cart
NU817-5UC - (0.5 mL (Conc.))Add to cart
NU817-UC - (1 mL(Conc.))Add to cart

Breast cancer tissue stained with anti-Human p27/Kip1using DAB chromogen

p27/Kip1 is a cyclin kinase inhibitor involved in G1 arrest. p27/Kip1 binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (1). p27/Kip1 is regulated by phosphorylation on serine 10 (s10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitination and degradation of p27/Kip1, while phosphorylation by hKIS on S10 signals nuclear export to the cytoplasm. The expression level of p27/Kip1 is high in normal cells. Downregulation of p27/Kip1 is found in many types of cancers, and decreased expression of p27/Kip1 appears to be a poor prognostic factor in several tumor models, including carcinomas of the lung, breast, colorectal, and prostate.
Intended Use: IVD