Anti-PD-1, Clone IHC001

Catalog Number
AM922-10M
(10 mL (RTU))
Qty:
AM922-5M
(6 ml (RTU))
Qty:
AX922-50D
(50 tests - Xmatrx Elite/Ultra)
Qty:
AX922-YCD
(200 tests - Xmatrx Elite/Ultra)
Qty:
MU922-5UC
(0.5 ml (Conc.))
Qty:
MU922-UC
(1 ml (Conc.))
Qty:
Datasheet
SDS

Lymph node stained with PD-1.

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PD-1 also known as programmed cell death protein-1 is a cell surface receptor that belongs to the CD28 immunoglobulin super family and is expressed on activated T cells, B cells and NK cells. Studies have shown that PD-1/PD-L interaction function as an immune checkpoint for induction and maintenance of T-cells involved in peripheral tolerance and protects tissues from autoimmune attack. PD-1 down regulates the immune system which in turn reduces autoimmunity and promotes self-tolerance. In a tumor microenvironment, cancer cells utilize this PD-1/PD-L1 mechanism of immune suppression which confers survival advantage to the cancer cells.