Anti-PD-1, Clone IHC001

Catalog Number
AM922-10M - (10 mL (RTU))Add to cart
AM922-5M - (6 mL (RTU))Add to cart
AX922-50D - (50 tests - Xmatrx Elite)Add to cart
AX922-YCD - (200 tests - Xmatrx Elite)Add to cart
MU922-5UC - (0.5 mL (Conc.))Add to cart
MU922-UC - (1 mL(Conc.))Add to cart

Lymph node stained with PD-1.

PD-1 also known as programmed cell death protein-1 is a cell surface receptor that belongs to the CD28 immunoglobulin super family and is expressed on activated T cells, B cells and NK cells. Studies have shown that PD-1/PD-L interaction function as an immune checkpoint for induction and maintenance of T-cells involved in peripheral tolerance and protects tissues from autoimmune attack. PD-1 down regulates the immune system which in turn reduces autoimmunity and promotes self-tolerance. In a tumor microenvironment, cancer cells utilize this PD-1/PD-L1 mechanism of immune suppression which confers survival advantage to the cancer cells.