Anti-PD-L1, Clone IHC411

Catalog Number
AN921-10M - (10 mL (RTU))Add to cart
AN921-5M - (6 mL (RTU))Add to cart
AY921-50D - (50 tests - Xmatrx Elite)Add to cart
AY921-YCD - (200 tests - Xmatrx Elite)Add to cart
NU921-5UC - (0.5 mL (Conc.))Add to cart
NU921-UC - (1 mL(Conc.))Add to cart

Lung tissue stained with PD-L1 showing membrane staining.

PD-L1 (Programmed death ligand 1) or B7 homolog 1 (B7-H1) is immunoglobulin-like type I transmembrane glycoprotein that acts as a ligand for programmed death 1 (PD-1). PD-L1 upon interaction with its receptor PD-1 delivers inhibitory signals to activated T cells and B cells and thus helps to maintain the balance between effective immunity, tolerance and immunopathology. In a tumor microenviroment, cancer cells upregulate PD-L1 expression - this PD-1/PDL-1 interaction axis helps in evading anti-tumor responses and promotes cancer-associated immune suppression.