Anti-PU.1

Catalog Number
AN843-10M
(100 tests - i6000)
Qty:
AN843-5M
(6 ml (RTU))
Qty:
AY843-50D
(50 tests - Xmatrx Elite/Ultra)
Qty:
AY843-YCD
(200 tests - Xmatrx Elite/Ultra)
Qty:
FB-843N
(5 slides - Xmatrx)
Qty:
FG-843N
(5 slides - Manual)
Qty:
NU843-5UC
(0.5 ml (Conc.))
Qty:
NU843-UC
(1 ml (Conc.))
Qty:
Datasheet
SDS

Lymphoma stained with anti-Human PU.1 using DAB chromogen

$0.00
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PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B cell development. PU.1 stains B lymphocyte in germinal center and mantle B cell, but not plasma cell. It labels many types of B cell lymphoma including mantle cell lymphoma, but it is not expressed in classical Hodgkin lymphoma (cHL). The lack of transcription factor PU.1 protein expression in cHL, a lympho proliferative disease of predominantly B-cell origin, likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHL.
Intended Use: IVD