Anti-Topoisomerase II, Alpha (TOP2A)

Catalog Number
AN823-10M - (100 tests - i6000)Add to cart
AN823-5M - (6 mL (RTU))Add to cart
AY823-50D - (50 tests - Xmatrx Elite)Add to cart
AY823-YCD - (200 tests - Xmatrx Elite)Add to cart
FB-823N - (5 slides - Xmatrx)Add to cart
FG-823N - (5 slides - Manual)Add to cart
NU823-5UC - (0.5 mL (Conc.))Add to cart
NU823-UC - (1 mL(Conc.))Add to cart
Datasheet
SDS

Breast cancer tissue stained with anti-Human Topoisomerase II alpha using DAB chromogen

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DNA topoisomerase II alpha (Topo-IIα) is an essential nuclear enzyme with its up-regulation demonstrated in different tumors. Topo II is required in chromatin condensation and segregation during mitosis. Topo II α is cell cycle regulated and its level peaks between G2 and M phase. It has been linked to cell proliferation and it may be the main isoform of Topo II involved mitotic processes. Topo II α passes one strand of DNA through a reversible break in a second DNA strand, which catalyzes the topological isomerization of DNA during cell cycle. Topo II α overexpression has been linked to a number of human malignancies and is the target for many chemotherapeutic agents. The majority of anticancer drugs targeting Topo IIα initiate apoptosis by stabilizing the covalent complex formed between DNA and Topo IIα.
Intended Use: IVD