CCND1 Dual Color Break Apart Probe

Catalog Number
FP069-10X
(10 tests(RTU))
Qty:
FP069-20X
(20 tests(RTU))
Qty:
Datasheet
SDS

Bone marrow biopsy section with translocation affecting the 11q13 locus as indicated by one non-rearranged orange/green fusion signal, one orange signal, and one separate green signal indicating the translocation).

eFISH CCND1 Dual Color Break Apart Probe hybridized to normal interphase cells as indicated by two orange/green fusion signals per nucleus.

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Translocations involving the chromosomal region 11q13 harboring the CCND1 gene has affinity to eFISH CCND1 Dual Color Break Apart Probe. The CCND1 gene (cyclin D1, a.k.a. PRAD1) encodes a regulatory subunit of cyclin dependent kinases. eFISH CCND1 Dual Color Break Apart Probe is a mixture of two direct labeled probes hybridizing to the 11q13 band. The orange fluorochrome direct labeled probe hybridizes distal to and covers the CCDN1 gene, while the green fluorochrome direct labeled probe hybridizes proximal to that gene.
Intended Use: RUO