EGFR/CEN 7 Dual Color Probe

Catalog Number
FP040-10X
(10 tests(RTU))
Qty:
FP040-20X
(20 tests(RTU))
Qty:
Datasheet
SDS

Cells with multiple copies of chromosome 7 and extra EGFR signals (green).

eFISH EGFR/CEN 7 Dual Color Probe hybridized to normal interphase cells as indicated by two orange and two green signals in each nucleus.

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EGFR gene amplification frequently observed in solid neoplasms. eFISH EGFR/CEN 7 Dual Color Probe has affinity to this gene. The EGFR gene (a.k.a. ERBB1 and HER1) is located in the chromosomal region 7p11.2 and encodes a transmembrane glycoprotein acting as a cellular growth factor receptor. The use of BioGenex eFISH EGFR/CEN7 in interphase and normal chromosome 7 produces two EGFR signals and two chromosome 7 signals. These signals appear green with hybridized EGFR probe and orange when hybridized to alpha-satellite-sequences of centromere of chromosome 7, when appropriate filter sets are used. In cases of increased gene amplification in these regions, an increased number of gene signals are visible.
Intended Use: RUO