ALK Dual Color Break Apart Probe

Catalog Number
FP056-10X - (10 tests(RTU))Add to cart
FP056-20X - (20 tests(RTU))Add to cart

Tissue section with translocation affecting the 2p23 locus as indicated by one orange/green fusion (non rearranged) signal one orange signal and one separate green signal indicating the translocation.

eFISH ALK Dual Color Break Apart Probe hybridized to normal interphase cells as indicated by two orange/green fusion signals per nucleus.

Rearrangements involving the chromosomal region 2p23 harboring the ALK (anaplastic lymphoma receptor tyrosine kinase, a.k.a. CD246) gene has affinity by eFISH ALK Dual Color Break Apart Probe. ALK encodes a transmembrane receptor tyrosine kinase. The use of eFISH ALK Dual Color Break Apart Probe along with appropriate filters produces orange and green signal for hybridization regions of chromosomal region 2p23. Normal interphase cells or cells without 2p23 translocation, two orange/two green fusion signals appear. In regions where 2p23 is affected by translocation, one separate green signal and one separate orange signal are observed.
Intended Use: RUO