PDGFB Dual Color Break Apart Probe

Catalog Number
(10 tests(RTU))
(20 tests(RTU))

Tissue section with translocation affecting the 22q13 locus as indicated by one non-rearranged orange/green fusion signal one orange signal and one separate green signal indicating the translocation.

PDGFB Dual Color Break Apart Probe hybridized to normal interphase cells as indicated by two orange/green fusion signals per nucleus.

The specific translocations involving the chromosomal region 22q13 harboring the PDGFB (a.k.a. SIS) gene has affinity by eFISH PDGFB Dual Color Break Apart Probe. The PDGFB gene (platelet-derived growth factor beta polypeptide) belongs to the platelet-derived growth factor family and encodes a protein which acts as a receptor tyrosine kinase. The most frequent translocation involving the PDGFB gene is t(17;22)(q22;q13) juxtaposing the PDGFB gene next to the COL1A1 gene in 17q22. The use of eFISH PDGFB Dual Color Break Apart Probe along with appropriate filters produces orange and green signal for hybridization regions of 22q13. Normal interphase cells or cells without 22q13 translocation, two orange/two green fusion signals appear. In regions where 22q13 is affected by translocation, one separate green signal and one separate orange signal are observed.
Intended Use: RUO