TFE3 Dual Color Break Apart Probe

Catalog Number
(10 tests(RTU))
(20 tests(RTU))

Tissue section with translocation affecting the Xp11.2 locus as indicated by one non-rearranged orange/green fusion signal, one orange signal and one separate green signal indicating the translocation.

eFISH TFE3 Dual Color Break Apart Probe hybridized to normal interphase cells as indicated by two orange/green fusion signals per nucleus.

Translocations involving the chromosomal region Xp11.2 harboring the TFE3 (transcription factor binding to IGHMenhancer 3, a.k.a. TFEA) gene has affinity by BioGenex eFISH TFE3 Dual Color Break Apart Probe. The use eFISH TFE3 Dual Color Break Apart Probe along with appropriate filters produces green and orange hybridization signals of Xp11 chromosomal region. In normal interphase male cells without translocation, one green/orange fusion signal is produced where as normal interphase cells or female cells without translocation two green/orange fusion signals are observed. Where as an indication of translocation is observed by the appearance of one separate green and orange signal.
Intended Use: RUO