TP53/CEN 17 Dual Color Probe

Catalog Number
FP062-10X
(10 tests(RTU))
Qty:
FP062-20X
(20 tests(RTU))
Qty:
Datasheet
SDS

TP53/CEN 17 Dual Color Probe hybridized to tissue section with deletion of the TP53 gene as indicated by one orange signal and two green signals in each nucleus.

TP53/CEN 17 Dual Color Probe hybridized to normal interphase cells as indicated by two orange and two green signals in each nucleus.

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eFISH TP53/CEN 17 Dual color Probe has affinity to TP53 gene deletions. The TP53 gene (tumor protein 53, a.k.a. p53, BCC7, LFS1, and TRP53) is located in the chromosomal region 17p13.1 and encodes a 53 kDa transcription factor which regulates cell proliferation, differentiation, and apoptosis and which functions as a tumor suppressor by activating the expression of genes that inhibit cell growth. Deletions affecting the short arm of chromosome 17 (17p), the site of the TP53 gene, are often accompanied by mutations in the remaining allele, and thus result in the loss of TP53 tumor suppressor activity. eFISH TP53/CEN 17 Dual Color Probe is a mixture of a green fluorochrome direct labeled CEN 17 probe specific for the alpha satellite centromeric region of chromosome 17 (D17Z1) and an orange fluorochrome direct labeled TP53 probe specific for the TP53 gene at 17p13.1
Intended Use: RUO