VHL/CEN 3 Dual Color Probe

Catalog Number
(10 tests(RTU))
(20 tests(RTU))

Trisomy of chromosome 3 as indicated by three orange (CEN 3) and three green (VHL) signals in each nucleus.

eFISH VHL/CEN 3 Dual Color Probe hybridized to normal interphase cells as indicated by two orange and two green signals in each nucleus

eFISH VHL/CEN 3 Dual Color Probe has affinity for VHL gene. The tumor suppressor gene VHL (von Hippel-Lindau) is located on 3p25.3 and encodes a 30 kDa protein with ubiquitin ligase E3 activity. The protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a critical role in the regulation of gene expression by oxygen. The BioGenex eFISH VHL/CEN 3 Dual Color Probe is a mixture of an orange fluorochrome direct labeled CEN 3 probe specific for the alpha satellite centromeric region of chromosome 3 (D3Z1) and a green fluorochrome direct labeled VHL probespanning the VHL gene at 3p25.3.
Intended Use: RUO