Anti-Beta-Catenin, Clone E247

Catalog Number
AX510-50D
(50 tests - Xmatrx Elite/Ultra)
Qty:
AX510-YCD
(200 tests - Xmatrx Elite/Ultra)
Qty:
FG-510N
(5 slides - Manual)
Qty:
NU510-5UC
(0.5 ml (Conc.))
Qty:
NU510-UC
(1 ml (Conc.))
Qty:
Datasheet
SDS
$0.00
0
ß-catenin is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation. ß-catenin is phosphorylated at four serine and threonine residues at the N-terminus. Ser 45 is phosphorylated by CK1, and is thought to be a priming site for the phosphorylation by glycogen synthase kinase-3 (GSK-3) of the remaining three residues, Thr 41, Ser 37, and Ser 33 . Wnt signaling antagonizes the action of GSK-3, which in subsequent phosphorylation steps, leads to its degradation . Mutations in the -catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas.
Intended Use: IVD