Anti-ZAP-70, Clone ZAP70-C3

Catalog Number
AM544-10M
(100 tests - i6000)
Qty:
AM544-5M
(6 ml (RTU))
Qty:
AX544-50D
(50 tests - Xmatrx Elite/Ultra)
Qty:
AX544-YCD
(200 tests - Xmatrx Elite/Ultra)
Qty:
FG-544M
(5 slides - Manual)
Qty:
MU544-5UC
(0.5 ml (Conc.))
Qty:
MU544-UC
(1 ml (Conc.))
Qty:
Datasheet
SDS

Tonsil tissue stained with Anti-ZAP-70 using DAB chromogen

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ZAP-70 is an abbrevation for Zeta-chain-associated protein kinase 70 (70 is the molecularweight in kDa). The protein is a member in the protein-tyrosine kinase family. ZAP-70 isnormally expressed in T cells and natural killer cells and has a critical role in the initiation of T-cell signaling. ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). ZAP-70 protein is expressed in leukemic cells of approximately 25% of Chronic Lymphocytic Leukemia (CLL) cases as well. ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses.
Intended Use: IVD