MicroRNAs (miRNAs) are endogenous, non-coding small RNAs known to regulate gene expression by translational repression or RNA cleavage. Recent studies on tissue-specific tumor markers indicated that miRNA expression is correlated with tumor signature and miRNA is frequently regulated in cancer. This fact indicated a differential expression pattern of miRNA in normal, neoplastic, pre-malignant and malignant tissues. Therefore, in situ detection of miRNA differential expression in different stages of cancer makes the expression profiling a potential tool not only for cancer characterization but also for accurate Carcinoma of Unknown Primary (CUP) characterization and disease management.

The miRNA probes offered by BioGenex are a next-generation tool for the detection and characterization of in situ tissue signature markers. Using BioGenex’s proprietary technology, our miRNA probes are highly specific and sensitive to deliver clean and intense stains for in situ context of tissue morphology. Our miRNA products come with ready-to-use reagents and optimized protocols for standardized manual ISH staining on FFPE tissues.