PIK3CA/CEN 3 Dual Color Probe

Catalog Number
FP059-10X
(10 tests(RTU))
Qty:
FP059-20X
(20 tests(RTU))
Qty:
Datasheet
SDS

Human cell line with amplification of the PIK3CA gene as indicated by multiple green signals in each nucleus.

eFISH PIK3CA/CEN 3 Dual Color Probe hybridized to normal interphase cells as indicated by two Orange and two green signals in each nucleus.

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eFISH PIK3CA/CEN 3 Dual Color Probe has affinity to PIK3CA gene. The PIK3CA (a.k.a. PI3K-alpha) gene is located on chromosome 3q26.3 and encodes the 110 kDa catalytic subunit of the phosphatidylinositol 3-kinase (PI3K). The use of eFISH PIK3CA/CEN 3 Dual Color Probe along with appropriate filters produces green signal for PIK3CA gene and the hybridization signals of the labeled alpha-satellite-sequences of the centromere of chromosome 3 appear orange. Normal interphase cells or cells without aberrations of chromosome 3, two PIK3CA signals and two chromosome 3 signals appear. Cells with a gene amplification have an increased number of gene specific signals or signal clusters.
Intended Use: RUO