Research Platforms
BioGenex is a pioneer in the design, development and manufacturing of advanced systems for automation of cell and tissue-based staining. The Xmatrx research systems (NANO, MINI and Infinity) are the direct result of our platform technology innovation. They offer a variety of automation, throughput and assay applications for translational and clinical research. Our key technology differentiators, including the eXACT temperature control and reaction micro-chamber, enable any slide-based assays such as immunohistochemistry (IHC), in situ hybridization (ISH), fluorescence in situ hybridization (FISH), immuno-fluorescence (IF), co-detection and multiplex applications (double and triple stains; IHC/ISH), in situ PCR, micro-RNA and special staining.
The i6000 Elite Rx is a high-throughput open-system platform for IHC and Special-Stain staining with a capacity of 200 slides in 8 hours using BioGenex Protocols. The system is supplied together with the EZ-Retriever®, for Microwave-based Dewaxing and Antigen Retrieval. The Xmatrx and i6000 platforms meet globally accepted quality standards (ISO13485:2003 & ISO9001:2008), improve laboratory workflow, productivity and reproducibility, and are intended for clinical research (RUO) in the US.
1. Xmatrx Infinity:
Features & Benefits:
- Intelligent and flexible system offering infinite possibilities – IHC, IF ISH, FISH, CISH, IF, Multiplexing and in situ PCR.
- Simultaneous optimization of up to 40 parameters in single run
- Reaction micro-chamber reduces micro-reagent consumption by up to 90%
- 40 independent thermocyclable (PCR) workstations
- Intuitive software designed for ease of use and flexibility
- Reports for inventory management and regulatory compliance
- Multiple slide processing options – Random, Continuous and STAT
2. Xmatrx Nano:
Features & Benefits:
- All-in-One – FISH, in situ PCR and ISH
- Add micro-reagents manually to save cost
- Intelligent SMS alerts for manual intervention steps
- Economical and affordable
- Flexible open system software - to create, edit and save protocols for future use
- Run 10 different protocols simultaneously
3. Xmatrx Mini:
Features & Benefits:
- in situ PCR and FISH Work Station
- Hybridizer with eXACT™ temperatures
- 10 independent thermal cyclers
- Built-in touch screen display for easy operations
- On-board wash with effective waste drainage system
- Audio-visual alerts at every step for manual intervention
- User-friendly software with ability to add or delete cycles, store protocols for future use and perform up to 45 PCR cycles
4. i6000 Elite Rx Automated Staining Systems:
Features & Benefits:
- Multi-functional System for IHC, IF and Special Stains
- Fully open system to customize any manual protocol
- High capacity: 60 slides and 53 antibodies per run
- Works seamlessly with EZ-Retriever® for Eco-friendly De-waxing, Rehydration and Antigen Retrieval
- Reagent dispense volumes: 100 μL to 900 μL
- Liquid level sensor for accurate reagent dispensing
- Audio-visual alerts at every step for manual intervention
- Multiple slide processing options – Random, Continuous and STAT
EZ-Retriever®
Programmable Microwave oven with built in temperature control
- High capacity: 60 slides and 53 antibodies per run. 200 slides in 8 hours
- Greater reproducibility Dewaxing, Rehydration, and Antigen Retrieval
- Preserved tissue morphology with fast uniform heating & cooling of AR solutions
- High Throughput - 96 Slides / 35 minutes
- Optimized factory protocols for convenience and consistent results
- AR solutions are non-hazardous, non-flammable and odorless
- Compliance to CLSI (Clinical and Laboratory Standards Institute) guidelines
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Xmatrx Infinity |
Xmatrx Nano |
Xmatrx Mini |
i6000 Elite Rx |
|
|
SPECIFICATIONS |
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|
Automation |
Full (Baking through cover slipping) |
Semi |
Work Station |
Automated. Supplied with EZ-Retriever® for Dewax & Antigen retrieval |
|
Run Time (full slide load) |
Open System / User defines |
Open System / User defines |
Open System / User defines |
Open System / User defines |
|
Temperature Range |
Ambient to 105oC |
Ambient to 105oC |
Ambient to 105oC |
NA |
|
Reagent Dispensing Volume |
10-850 µl |
NA |
NA |
100-900 µl |
|
Slide Capacity |
40 |
10 |
10 |
60 |
|
Reagent Capacity |
30 |
NA |
NA |
60 |
|
Reader |
NA |
NA |
NA |
NA |
|
Bulk Reagent Carboy |
7 x 4 L |
6 x 1 L |
NA |
2 x 10 L |
|
Waste Container |
8 L |
4 L |
2 L |
20 L |
|
Touch Screen |
NA |
NA |
✓ |
NA |
|
SMS Prompt |
NA |
✓ |
NA |
NA |
|
Protocols |
Template / Self |
Template / Self |
Template / Self |
Template / Self |
|
Dimensions |
29”D, 46”W, 59”H |
20”D, 30”W, 15.7”H |
19.5”D, 13”W, 8”H |
24”D, 40.5”W, 18.5”H |
|
Weight |
400 lb/ 182 kg |
106 lb/ 48 kg |
30 lb/ 13.6 kg |
130 lb / 59 kg |
|
APPLICATIONS |
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|
IHC |
✓ |
NA |
NA |
✓ |
|
ISH / CISH |
✓ |
✓ |
✓ |
NA |
|
Double Staining |
✓ |
NA |
NA |
✓ |
|
Special Stains |
✓ |
NA |
NA |
✓ |
|
FISH |
✓ |
✓ |
✓ |
NA |
|
IF |
✓ |
✓ |
✓ |
✓ |
|
miRNA - ISH |
✓ |
✓ |
✓ |
NA |
|
Multiplexing (ISH + IHC) |
✓ |
NA |
NA |
NA |
|
In-Situ PCR |
✓ |
✓ |
✓ |
NA |
